BDBM291361 2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-ylmethyl-pyrido[3′,2′:4,5]furo[3,2d]pyrimidine::US9580442, Example I::US9938290, I

SMILES: C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1

InChI Key: InChIKey=VHMNKJYBSMIIBI-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 291361   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	508	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	503	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	508	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	503	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Lek Pharmaceuticals d.d.					Assay Description Please see article				J Med Chem 51: 7486-94 (2008) BindingDB Entry DOI: 10.7270/Q21V5H9P
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM291361 (2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...) Show SMILES C(N1CCCCC1)c1cnc2oc3c(nc(nc3c2c1)-c1cccc2[nH]ccc12)N1CCOCC1 Show InChI InChI=1S/C27H28N6O2/c1-2-9-32(10-3-1)17-18-15-21-23-24(35-27(21)29-16-18)26(33-11-13-34-14-12-33)31-25(30-23)20-5-4-6-22-19(20)7-8-28-22/h4-8,15-16,28H,1-3,9-14,17H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Karus Therapeutics Limited US Patent					Assay Description PI3K Isoform using biochemical assay.				US Patent US9580442 (2017) BindingDB Entry DOI: 10.7270/Q2J38VM2
					More data for this Ligand-Target Pair