BDBM292054 5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,3-b]pyridin-3-yl)-7-::US10100045, Example 25

SMILES: Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1

InChI Key: InChIKey=MHHPGGXZAMHNQW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292054   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292054 (5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 Show InChI InChI=1S/C20H17F3N4O/c1-10-7-12(8-11-9-16(28)25-17(10)11)19-18-14(26-27(19)13-3-2-4-13)5-6-15(24-18)20(21,22)23/h5-8,13H,2-4,9H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair