BDBM292455 (R)-(2-(aminomethyl)piperidin-1-yl)(2-chloro-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-4-yl)methanone::US10100058, Example 111

SMILES: NC[C@H]1CCCCN1C(=O)c1cc(Cl)nc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key: InChIKey=AUEYASNPQJYJNJ-OAHLLOKOSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292455 ((R)-(2-(aminomethyl)piperidin-1-yl)(2-chloro-6-(5-...) Show SMILES NC[C@H]1CCCCN1C(=O)c1cc(Cl)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C22H21ClN6OS/c23-20-11-14(22(30)28-7-2-1-4-15(28)12-24)10-18(26-20)16-13-25-29-8-6-17(27-21(16)29)19-5-3-9-31-19/h3,5-6,8-11,13,15H,1-2,4,7,12,24H2/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	23.7	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292455 ((R)-(2-(aminomethyl)piperidin-1-yl)(2-chloro-6-(5-...) Show SMILES NC[C@H]1CCCCN1C(=O)c1cc(Cl)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C22H21ClN6OS/c23-20-11-14(22(30)28-7-2-1-4-15(28)12-24)10-18(26-20)16-13-25-29-8-6-17(27-21(16)29)19-5-3-9-31-19/h3,5-6,8-11,13,15H,1-2,4,7,12,24H2/t15-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair