null
SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(O)C1
InChI Key: InChIKey=OFBABNCAYHDFSH-KRWDZBQOSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human)) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human)) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | n/a | n/a | 17.7 | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ERG | Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta/gamma (Rattus norvegicus) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article | n/a | n/a | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CaMK2gamma/delta in neonatal rat ventricular myocytes assessed as phospholamban phosphorylation after 4 hrs by Hoechst 33342 fluorescen... | Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit beta (Rattus norvegicus) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article | n/a | n/a | n/a | n/a | 274 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of CaMK2alpha/beta in neonatal rat cortical neurons assessed as phospholamban phosphorylation after 4 hrs by Hoechst 33342 fluorescence-ba... | Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human)) | BDBM292489 ((S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in pres... | Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |