BDBM292497 (S)-N-(2-(diethylamino)propyl)-2-(3-fluoroazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 153

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(F)C1

InChI Key: InChIKey=JMBAXWLHLKJCLO-KRWDZBQOSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292497 ((S)-N-(2-(diethylamino)propyl)-2-(3-fluoroazetidin...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(F)C1 |r| Show InChI InChI=1S/C26H30FN7OS/c1-4-32(5-2)17(3)13-28-26(35)18-11-22(30-24(12-18)33-15-19(27)16-33)20-14-29-34-9-8-21(31-25(20)34)23-7-6-10-36-23/h6-12,14,17,19H,4-5,13,15-16H2,1-3H3,(H,28,35)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	20.5	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292497 ((S)-N-(2-(diethylamino)propyl)-2-(3-fluoroazetidin...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(F)C1 |r| Show InChI InChI=1S/C26H30FN7OS/c1-4-32(5-2)17(3)13-28-26(35)18-11-22(30-24(12-18)33-15-19(27)16-33)20-14-29-34-9-8-21(31-25(20)34)23-7-6-10-36-23/h6-12,14,17,19H,4-5,13,15-16H2,1-3H3,(H,28,35)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair