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BDBM292509 (S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidin-1-yl)-6-(5-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 165

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccsc1)N1CC(C1)OC

InChI Key: InChIKey=TUZUKKWMTNYGHX-SFHVURJKSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292509   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)


(Homo sapiens (Human))
BDBM292509
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccsc1)N1CC(C1)OC |r|
Show InChI InChI=1S/C27H33N7O2S/c1-5-32(6-2)18(3)13-28-27(35)20-11-24(30-25(12-20)33-15-21(16-33)36-4)22-14-29-34-9-7-23(31-26(22)34)19-8-10-37-17-19/h7-12,14,17-18,21H,5-6,13,15-16H2,1-4H3,(H,28,35)/t18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 14.9n/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)


BindingDB Entry DOI: 10.7270/Q2V98B4F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)


(Homo sapiens (Human))
BDBM292509
PNG
((S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidi...)
Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccsc1)N1CC(C1)OC |r|
Show InChI InChI=1S/C27H33N7O2S/c1-5-32(6-2)18(3)13-28-27(35)20-11-24(30-25(12-20)33-15-21(16-33)36-4)22-14-29-34-9-7-23(31-26(22)34)19-8-10-37-17-19/h7-12,14,17-18,21H,5-6,13,15-16H2,1-4H3,(H,28,35)/t18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...


US Patent US10100058 (2018)


BindingDB Entry DOI: 10.7270/Q2V98B4F
More data for this
Ligand-Target Pair