BDBM292529 (S)-N-(2-(diethylamino)propyl)-2-(3-ethylureido)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 185

SMILES: CCNC(=O)Nc1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC

InChI Key: InChIKey=GLVFOYIBHYNBTG-KRWDZBQOSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292529   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292529 ((S)-N-(2-(diethylamino)propyl)-2-(3-ethylureido)-6...) Show SMILES CCNC(=O)Nc1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC |r| Show InChI InChI=1S/C26H32N8O2S/c1-5-27-26(36)32-23-14-18(25(35)28-15-17(4)33(6-2)7-3)13-21(30-23)19-16-29-34-11-10-20(31-24(19)34)22-9-8-12-37-22/h8-14,16-17H,5-7,15H2,1-4H3,(H,28,35)(H2,27,30,32,36)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.83	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292529 ((S)-N-(2-(diethylamino)propyl)-2-(3-ethylureido)-6...) Show SMILES CCNC(=O)Nc1cc(cc(n1)-c1cnn2ccc(nc12)-c1cccs1)C(=O)NC[C@H](C)N(CC)CC |r| Show InChI InChI=1S/C26H32N8O2S/c1-5-27-26(36)32-23-14-18(25(35)28-15-17(4)33(6-2)7-3)13-21(30-23)19-16-29-34-11-10-20(31-24(19)34)22-9-8-12-37-22/h8-14,16-17H,5-7,15H2,1-4H3,(H,28,35)(H2,27,30,32,36)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair