BDBM292569 (S)-N-(2-(diethylamino)propyl)-2-((2-methoxyethyl)amino) 6 (5 (thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 225

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCOC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key: InChIKey=INEJCFWLGXNWSN-SFHVURJKSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 292569   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292569 ((S)-N-(2-(diethylamino)propyl)-2-((2-methoxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCOC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C26H33N7O2S/c1-5-32(6-2)18(3)16-28-26(34)19-14-22(30-24(15-19)27-10-12-35-4)20-17-29-33-11-9-21(31-25(20)33)23-8-7-13-36-23/h7-9,11,13-15,17-18H,5-6,10,12,16H2,1-4H3,(H,27,30)(H,28,34)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292569 ((S)-N-(2-(diethylamino)propyl)-2-((2-methoxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCOC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C26H33N7O2S/c1-5-32(6-2)18(3)16-28-26(34)19-14-22(30-24(15-19)27-10-12-35-4)20-17-29-33-11-9-21(31-25(20)33)23-8-7-13-36-23/h7-9,11,13-15,17-18H,5-6,10,12,16H2,1-4H3,(H,27,30)(H,28,34)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in pres...				Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (Homo sapiens (Human))	BDBM292569 ((S)-N-(2-(diethylamino)propyl)-2-((2-methoxyethyl)...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCOC)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r| Show InChI InChI=1S/C26H33N7O2S/c1-5-32(6-2)18(3)16-28-26(34)19-14-22(30-24(15-19)27-10-12-35-4)20-17-29-33-11-9-21(31-25(20)33)23-8-7-13-36-23/h7-9,11,13-15,17-18H,5-6,10,12,16H2,1-4H3,(H,27,30)(H,28,34)/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	43.7	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair