BDBM292587 N-((S)-2-(diethylamino)propyl)-2-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 243

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1C[C@H](O)[C@@H](O)C1

InChI Key: InChIKey=OZKGXUIZSBKULM-RTFZILSDSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292587 (N-((S)-2-(diethylamino)propyl)-2-((3S,4S)-3,4-dihy...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1C[C@H](O)[C@@H](O)C1 |r| Show InChI InChI=1S/C27H33N7O3S/c1-4-32(5-2)17(3)13-28-27(37)18-11-21(30-25(12-18)33-15-22(35)23(36)16-33)19-14-29-34-9-8-20(31-26(19)34)24-7-6-10-38-24/h6-12,14,17,22-23,35-36H,4-5,13,15-16H2,1-3H3,(H,28,37)/t17-,22-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292587 (N-((S)-2-(diethylamino)propyl)-2-((3S,4S)-3,4-dihy...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1C[C@H](O)[C@@H](O)C1 |r| Show InChI InChI=1S/C27H33N7O3S/c1-4-32(5-2)17(3)13-28-27(37)18-11-21(30-25(12-18)33-15-22(35)23(36)16-33)19-14-29-34-9-8-20(31-26(19)34)24-7-6-10-38-24/h6-12,14,17,22-23,35-36H,4-5,13,15-16H2,1-3H3,(H,28,37)/t17-,22-,23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair