BDBM292658 (S)-N-(2-(diethylamino)propyl)-2-(3-oxopiperazin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 314
SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CCNC(=O)C1
InChI Key: InChIKey=SKCIBMYZLKADNK-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human)) | BDBM292658 ((S)-N-(2-(diethylamino)propyl)-2-(3-oxopiperazin-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 96 | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human)) | BDBM292658 ((S)-N-(2-(diethylamino)propyl)-2-(3-oxopiperazin-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair |