BDBM292660 N-((S)-2-(diethylamino)propyl)-2-((R)-3-hydroxypyrrolidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 316
SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC[C@@H](O)C1
InChI Key: InChIKey=LLAKAURGXWLFGH-AZUAARDMSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human)) | BDBM292660 (N-((S)-2-(diethylamino)propyl)-2-((R)-3-hydroxypyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human)) | BDBM292660 (N-((S)-2-(diethylamino)propyl)-2-((R)-3-hydroxypyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human full length His-tagged CaMK2delta expressed in baculovirus using Biotin labelled STK1 as substrate after 1 hr in pres... | Citation and Details Article DOI: 10.1016/j.bmcl.2017.10.040 BindingDB Entry DOI: 10.7270/Q2930WR2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human)) | BDBM292660 (N-((S)-2-(diethylamino)propyl)-2-((R)-3-hydroxypyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 32.6 | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc. US Patent | Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ... | US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F | |||||||||||
More data for this Ligand-Target Pair |