BDBM292685 (S)-2-(1-(2-cyanoethyl)-1H-pyrazol-4-yl)-N-(2-(diethylamino)propyl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 341

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(CCC#N)c1

InChI Key: InChIKey=AUHUKZJHULRGBI-FQEVSTJZSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292685   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292685 ((S)-2-(1-(2-cyanoethyl)-1H-pyrazol-4-yl)-N-(2-(die...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(CCC#N)c1 |r| Show InChI InChI=1S/C29H31N9OS/c1-4-36(5-2)20(3)16-31-29(39)21-14-25(22-17-32-37(19-22)11-7-10-30)34-26(15-21)23-18-33-38-12-9-24(35-28(23)38)27-8-6-13-40-27/h6,8-9,12-15,17-20H,4-5,7,11,16H2,1-3H3,(H,31,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	12.8	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292685 ((S)-2-(1-(2-cyanoethyl)-1H-pyrazol-4-yl)-N-(2-(die...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)-c1cnn(CCC#N)c1 |r| Show InChI InChI=1S/C29H31N9OS/c1-4-36(5-2)20(3)16-31-29(39)21-14-25(22-17-32-37(19-22)11-7-10-30)34-26(15-21)23-18-33-38-12-9-24(35-28(23)38)27-8-6-13-40-27/h6,8-9,12-15,17-20H,4-5,7,11,16H2,1-3H3,(H,31,39)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair