BDBM292707 N-((S)-2-(diethylamino)propyl)-2-(5-(5-fluorothiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-6-((S)-2-(methylcarbamoyl)azetidin-1-yl)isonicotinamide::US10100058, Example 361

SMILES: CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccc(F)s1)N1CC[C@H]1C(=O)NC

InChI Key: InChIKey=XJGWFTPYUQAKSJ-JTSKRJEESA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292707 (N-((S)-2-(diethylamino)propyl)-2-(5-(5-fluorothiop...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccc(F)s1)N1CC[C@H]1C(=O)NC |r| Show InChI InChI=1S/C28H33FN8O2S/c1-5-35(6-2)17(3)15-31-27(38)18-13-21(33-25(14-18)36-11-10-22(36)28(39)30-4)19-16-32-37-12-9-20(34-26(19)37)23-7-8-24(29)40-23/h7-9,12-14,16-17,22H,5-6,10-11,15H2,1-4H3,(H,30,39)(H,31,38)/t17-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) (Homo sapiens (Human))	BDBM292707 (N-((S)-2-(diethylamino)propyl)-2-(5-(5-fluorothiop...) Show SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1ccc(F)s1)N1CC[C@H]1C(=O)NC |r| Show InChI InChI=1S/C28H33FN8O2S/c1-5-35(6-2)17(3)15-31-27(38)18-13-21(33-25(14-18)36-11-10-22(36)28(39)30-4)19-16-32-37-12-9-20(34-26(19)37)23-7-8-24(29)40-23/h7-9,12-14,16-17,22H,5-6,10-11,15H2,1-4H3,(H,30,39)(H,31,38)/t17-,22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...				US Patent US10100058 (2018) BindingDB Entry DOI: 10.7270/Q2V98B4F
					More data for this Ligand-Target Pair