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BDBM293312 US10106504, Example 49

SMILES: Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1

InChI Key: InChIKey=WWRAURCQYDDOEA-QNGWXLTQSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293312   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293312
PNG
(US10106504, Example 49)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1cc(F)c2OCCCc2c1 |r|
Show InChI InChI=1S/C39H42F2N2O4/c1-22-9-7-11-31(40)30(22)21-43-15-14-25-17-26(12-13-28(25)20-43)33-23(2)42-24(3)34(37(38(44)45)47-39(4,5)6)35(33)29-18-27-10-8-16-46-36(27)32(41)19-29/h7,9,11-13,17-19,37H,8,10,14-16,20-21H2,1-6H3,(H,44,45)/t37-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair