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BDBM293316 US10106504, Example 53

SMILES: Cc1nc(C)c(-c2ccc3CN(CCc3c2)c2ncnc3n(C)ncc23)c(-c2cc(F)c3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O

InChI Key: InChIKey=QUBISAPBKPXTNY-XIFFEERXSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293316   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293316
PNG
(US10106504, Example 53)
Show SMILES Cc1nc(C)c(-c2ccc3CN(CCc3c2)c2ncnc3n(C)ncc23)c(-c2cc(F)c3OCCCc3c2)c1[C@H](OC(C)(C)C)C(O)=O |r|
Show InChI InChI=1S/C37H39FN6O4/c1-20-29(23-9-10-25-18-44(12-11-22(25)14-23)35-27-17-41-43(6)34(27)39-19-40-35)31(26-15-24-8-7-13-47-32(24)28(38)16-26)30(21(2)42-20)33(36(45)46)48-37(3,4)5/h9-10,14-17,19,33H,7-8,11-13,18H2,1-6H3,(H,45,46)/t33-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair