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BDBM293321 US10106504, Example 58

SMILES: Cc1cc(nc(C)n1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1

InChI Key: InChIKey=JPUPORGLDBRGOA-DHUJRADRSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293321   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293321
PNG
(US10106504, Example 58)
Show SMILES Cc1cc(nc(C)n1)N1CCc2cc(ccc2C1)-c1c(C)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1 |r|
Show InChI InChI=1S/C37H42N4O4/c1-21-17-31(40-24(4)38-21)41-15-14-25-18-27(10-11-29(25)20-41)32-22(2)39-23(3)33(35(36(42)43)45-37(5,6)7)34(32)28-12-13-30-26(19-28)9-8-16-44-30/h10-13,17-19,35H,8-9,14-16,20H2,1-7H3,(H,42,43)/t35-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair