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BDBM293326 US10106504, Example 63

SMILES: Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1

InChI Key: InChIKey=LTWIHZJBLLMWQU-DHUJRADRSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293326   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293326
PNG
(US10106504, Example 63)
Show SMILES Cc1cccc(Cl)c1CN1CCc2cc(ccc2C1)-c1c(N)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1 |r|
Show InChI InChI=1S/C38H42ClN3O4/c1-22-8-6-10-30(39)29(22)21-42-16-15-24-18-27(11-12-28(24)20-42)34-33(26-13-14-31-25(19-26)9-7-17-45-31)32(23(2)41-36(34)40)35(37(43)44)46-38(3,4)5/h6,8,10-14,18-19,35H,7,9,15-17,20-21H2,1-5H3,(H2,40,41)(H,43,44)/t35-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair