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BDBM293331 US10106504, Example 68

SMILES: Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1

InChI Key: InChIKey=LOBYKYVBCPNFTO-SJARJILFSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293331   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HIV-1 Protease Chain A


(Human immunodeficiency virus type 1)		BDBM293331
PNG
(US10106504, Example 68)
Show SMILES Cc1cccc(F)c1CN1CCc2cc(ccc2C1)-c1c(CCCC2CCOCC2)nc(C)c([C@H](OC(C)(C)C)C(O)=O)c1-c1ccc2OCCCc2c1 |r|
Show InChI InChI=1S/C46H55FN2O5/c1-29-9-6-12-38(47)37(29)28-49-21-18-32-25-34(14-15-36(32)27-49)42-39(13-7-10-31-19-23-52-24-20-31)48-30(2)41(44(45(50)51)54-46(3,4)5)43(42)35-16-17-40-33(26-35)11-8-22-53-40/h6,9,12,14-17,25-26,31,44H,7-8,10-11,13,18-24,27-28H2,1-5H3,(H,50,51)/t44-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/a7.55n/a



ViiV HEALTHCARE UK (NO.5) LIMITED

US Patent


Assay Description
A recombinant NL-RLuc proviral clone was constructed in which a section of the nef gene from NL4-3 was replaced with the Renilla Luciferase gene. Thi...

US Patent US10106504 (2018)


BindingDB Entry DOI: 10.7270/Q2BC41K2
More data for this
Ligand-Target Pair