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SMILES: CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1sccc1Br

InChI Key: InChIKey=FSOUZKULNSRUHZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293959   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))		BDBM293959
PNG
(US10106552, Compound 34)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1sccc1Br |(-4.72,-4.01,;-3.95,-2.68,;-3.18,-4.01,;-4.86,-1.44,;-3.95,-.19,;-2.49,-.67,;-2.49,-2.21,;-1.15,-2.98,;.18,-2.21,;1.64,-2.68,;2.55,-1.44,;4.09,-1.44,;4.86,-.1,;4.86,-2.77,;1.64,-.19,;2.41,1.14,;.18,-.67,;-1.15,.1,;-1.15,1.64,;.09,2.55,;-.38,4.01,;-1.92,4.01,;-2.4,2.55,;-3.73,1.78,)|
Show InChI InChI=1S/C17H16BrN3OS2/c1-17(2)5-3-7-9(12-8(18)4-6-23-12)10-11(19)13(15(20)22)24-16(10)21-14(7)17/h4,6H,3,5,19H2,1-2H3,(H2,20,22)
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PC cid
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US Patent
n/an/a 800n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent


Assay Description
To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...

US Patent US10106552 (2018)


BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair