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SMILES: Cc1nc(C)c(s1)-c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12

InChI Key: InChIKey=SSABMVOYNIQRGI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 293966   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))		BDBM293966
PNG
(US10106552, Compound 41)
Show SMILES Cc1nc(C)c(s1)-c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12 |(.39,4.68,;-.38,3.35,;-1.92,3.35,;-2.4,1.88,;-3.73,1.11,;-1.15,.98,;.09,1.88,;-1.15,-.56,;-2.49,-1.33,;-3.95,-.86,;-4.86,-2.1,;-3.95,-3.35,;-4.72,-4.68,;-3.18,-4.68,;-2.49,-2.87,;-1.15,-3.64,;.18,-2.87,;1.64,-3.35,;2.55,-2.1,;4.09,-2.1,;4.86,-.77,;4.86,-3.44,;1.64,-.86,;2.41,.48,;.18,-1.33,)|
Show InChI InChI=1S/C18H20N4OS2/c1-7-13(24-8(2)21-7)10-9-5-6-18(3,4)15(9)22-17-11(10)12(19)14(25-17)16(20)23/h5-6,19H2,1-4H3,(H2,20,23)
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PC cid
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US Patent
n/an/a 500n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent


Assay Description
To determine the IC50 of compounds of the invention, recombinant eEF2K was diluted in an assay buffer in the presence of calmodulin, a calcium-bindin...

US Patent US10106552 (2018)


BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair