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SMILES: COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1

InChI Key: InChIKey=AATALYIJLBSKKQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 29432   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Rattus norvegicus (rat))		BDBM29432
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-1)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1
Show InChI InChI=1S/C20H27N5O3/c1-14-18(16-6-8-17(28-5)9-7-16)19-21-15(2)22-20(25(19)23-14)24(10-12-26-3)11-13-27-4/h6-9H,10-13H2,1-5H3
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Article
PubMed
n/an/a 11.5n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...

J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair