null
SMILES: COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
InChI Key: InChIKey=DKAPUZDMFUBEBM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat)) | BDBM29434 (Pyrazolo[1,5-a]-1,3,5-triazine, 12-3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | 7.2 | 23 |
Bristol-Myers Squibb Company | Assay Description Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so... | J Med Chem 52: 3073-83 (2009) Article DOI: 10.1021/jm9000242 BindingDB Entry DOI: 10.7270/Q23R0R6X | |||||||||||
More data for this Ligand-Target Pair |