BDBM295678 (R)-3-(2-(((S)-1-(1-(4-chloro-3-(trifluoromethoxy)phenyl)piperidin-4-yl)ethyl)amino)-5-fluoropyrimidin-4-yl)-4-((S)-1-hydroxyethyl)oxazolidin-2-one::US10112931, Example 28
SMILES: CC(O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)C2CCN(CC2)c2ccc(Cl)c(c2)C#[F][O](F)F)ncc1F
InChI Key: InChIKey=UWJKLSDVLIZTFE-TWZXDDCKSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) (Homo sapiens (Human)) | BDBM295678 ((R)-3-(2-(((S)-1-(1-(4-chloro-3-(trifluoromethoxy)...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
NOVARTIS AG US Patent | Assay Description Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc... | US Patent US10112931 (2018) BindingDB Entry DOI: 10.7270/Q2PG1TRT | |||||||||||
More data for this Ligand-Target Pair |