BDBM296101 2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylmethyl)-amino]-phenoxy}- pyrido[3,4-d]pyrimidin-4-ol::US10112940, Example 28::US10202381, Example 28::US10208039, Example 28::US10611763, Example 28::US10815234, Example 28
SMILES: CN(CC1CCCc2ccccc12)c1ccc(Oc2nc(O)c3ccncc3n2)cc1
InChI Key: InChIKey=VJRRSIKXEUZPHL-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM296101 (2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10112940 (2018) BindingDB Entry DOI: 10.7270/Q2X0692W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM296101 (2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ... | US Patent US10202381 (2019) BindingDB Entry DOI: 10.7270/Q2SX6GBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (JMJD2C)(2-372) (Homo sapiens (Human)) | BDBM296101 (2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...) | GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10815234 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM296101 (2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10611763 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM296101 (2-{4-[methyl-(1,2,3,4-tetrahydro- naphthalen-1-ylm...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate-format under the following reaction conditions: 0.3 ... | US Patent US10208039 (2019) BindingDB Entry DOI: 10.7270/Q241706J | |||||||||||
More data for this Ligand-Target Pair |