BDBM29638 1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-(furan-2-carbonyl)piperazin-1-yl]-3-propan-2-ylpyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-(furan-2-ylcarbonyl)piperazin-1-yl]-3-propan-2-yl-pyrido[1,2-a]benzimidazole-4-carbonitrile::1-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-3-propan-2-yl-4-pyrido[1,2-a]benzimidazolecarbonitrile::MLS000103510::SMR000018805::cid_1284208
SMILES: CC(C)c1cc(N2CCN(CC2)C(=O)c2ccco2)n2c3ccccc3nc2c1C#N
InChI Key: InChIKey=SIVCAUIKASCNMM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human)) | BDBM29638 (1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b (Homo sapiens (Human)) | BDBM29638 (1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 1.61E+4 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q280513R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human)) | BDBM29638 (1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
More data for this Ligand-Target Pair |