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SMILES: CCOC(=O)C(=O)NC(CC(O)C(O)=O)Cc1cc(Cl)c(cc1F)-c1cc(Cl)ccc1F

InChI Key: InChIKey=KPXLXODWGUYDKZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 298302   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM298302
PNG
(US10123984, Example 5-14)
Show SMILES CCOC(=O)C(=O)NC(CC(O)C(O)=O)Cc1cc(Cl)c(cc1F)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C21H19Cl2F2NO6/c1-2-32-21(31)19(28)26-12(8-18(27)20(29)30)5-10-6-15(23)13(9-17(10)25)14-7-11(22)3-4-16(14)24/h3-4,6-7,9,12,18,27H,2,5,8H2,1H3,(H,26,28)(H,29,30)
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KEGG

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US Patent
<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...

US Patent US10123984 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9DVB
More data for this
Ligand-Target Pair