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SMILES: CC(C)OC(=O)C(=O)NC(CC(O)C(O)=O)Cc1cc(Cl)c(cc1F)-c1cc(Cl)ccc1F

InChI Key: InChIKey=CWQRPPPMAZYKBQ-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 298303   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM298303
PNG
(US10123984, Example 5-15)
Show SMILES CC(C)OC(=O)C(=O)NC(CC(O)C(O)=O)Cc1cc(Cl)c(cc1F)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H21Cl2F2NO6/c1-10(2)33-22(32)20(29)27-13(8-19(28)21(30)31)5-11-6-16(24)14(9-18(11)26)15-7-12(23)3-4-17(15)25/h3-4,6-7,9-10,13,19,28H,5,8H2,1-2H3,(H,27,29)(H,30,31)
PDB

KEGG

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US Patent
<1n/an/an/an/an/an/an/an/a



THERAVANCE BIOPHARMA R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...

US Patent US10123984 (2018)


BindingDB Entry DOI: 10.7270/Q2KK9DVB
More data for this
Ligand-Target Pair