BDBM29840 spiro-carboxamide scaffold, 13

SMILES: O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1

InChI Key: InChIKey=KYTGICHJQRECNO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29840   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM29840 (spiro-carboxamide scaffold, 13) Show SMILES O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1 Show InChI InChI=1S/C19H25NO/c21-17(19(11-12-19)16-7-3-1-4-8-16)20-14-13-18(15-20)9-5-2-6-10-18/h1,3-4,7-8H,2,5-6,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.4	37
Merck-Serono					Assay Description 11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...				Bioorg Med Chem Lett 19: 3682-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.123 BindingDB Entry DOI: 10.7270/Q2X065DQ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM29840 (spiro-carboxamide scaffold, 13) Show SMILES O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1 Show InChI InChI=1S/C19H25NO/c21-17(19(11-12-19)16-7-3-1-4-8-16)20-14-13-18(15-20)9-5-2-6-10-18/h1,3-4,7-8H,2,5-6,9-15H2	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.8	22
Merck-Serono					Assay Description 11beta-HSD2 enzyme activity was assessed in buffer containing NAD, test compound, and human recombinant 11beta-HSD2 expressed in E. coli. Reaction wa...				Bioorg Med Chem Lett 19: 3682-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.123 BindingDB Entry DOI: 10.7270/Q2X065DQ
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM29840 (spiro-carboxamide scaffold, 13) Show SMILES O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1 Show InChI InChI=1S/C19H25NO/c21-17(19(11-12-19)16-7-3-1-4-8-16)20-14-13-18(15-20)9-5-2-6-10-18/h1,3-4,7-8H,2,5-6,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	377	n/a	n/a	n/a	n/a	7.4	37
Merck-Serono					Assay Description 11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...				Bioorg Med Chem Lett 19: 3682-5 (2009) Article DOI: 10.1016/j.bmcl.2009.02.123 BindingDB Entry DOI: 10.7270/Q2X065DQ
					More data for this Ligand-Target Pair