BDBM299394 (2S,4S)-5-(3′-Chlorobiphenyl-4-yl)-2-methoxymethyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid::US9593110, Example 3
SMILES: CCOC(=O)[C@H](COC)C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cnn[nH]1
InChI Key:
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neprilysin (Homo sapiens (Human)) | BDBM299394 ((2S,4S)-5-(3′-Chlorobiphenyl-4-yl)-2-methoxy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravence Biopharma R&D IP, LLC US Patent | Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp... | US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224 | |||||||||||
More data for this Ligand-Target Pair |