BDBM299397 1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluoro- phenyl] azetidine-3- carboxamide::US9592235, Example 190::US9855269, Compound 36

SMILES: CC(=O)N1CC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1

InChI Key: InChIKey=VVYCZBIUAJKJMS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299397   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299397 (1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluor...) Show SMILES CC(=O)N1CC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1 Show InChI InChI=1S/C20H18FN5O2/c1-11(27)26-8-14(9-26)20(28)25-16-5-13(4-15(21)7-16)12-2-3-18-17(6-12)19(22)24-10-23-18/h2-7,10,14H,8-9H2,1H3,(H,25,28)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299397 (1-acetyl-N-[3- (4-amino- quinazolin- 6-yl)-5-fluor...) Show SMILES CC(=O)N1CC(C1)C(=O)Nc1cc(F)cc(c1)-c1ccc2ncnc(N)c2c1 Show InChI InChI=1S/C20H18FN5O2/c1-11(27)26-8-14(9-26)20(28)25-16-5-13(4-15(21)7-16)12-2-3-18-17(6-12)19(22)24-10-23-18/h2-7,10,14H,8-9H2,1H3,(H,25,28)(H2,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair