BDBM299435 N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- (dimethylamino) acetamide::US9592235, Example 224::US9855269, Compound 71

SMILES: CN(C)CC(=O)Nc1cccc(c1)-c1ccc2ncnc(N)c2c1

InChI Key: InChIKey=TXHGOKBFQKJFFM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299435 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- (dimeth...) Show SMILES CN(C)CC(=O)Nc1cccc(c1)-c1ccc2ncnc(N)c2c1 Show InChI InChI=1S/C18H19N5O/c1-23(2)10-17(24)22-14-5-3-4-12(8-14)13-6-7-16-15(9-13)18(19)21-11-20-16/h3-9,11H,10H2,1-2H3,(H,22,24)(H2,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299435 (N-[3-(4-amino- quinazolin-6-yl) phenyl]-2- (dimeth...) Show SMILES CN(C)CC(=O)Nc1cccc(c1)-c1ccc2ncnc(N)c2c1 Show InChI InChI=1S/C18H19N5O/c1-23(2)10-17(24)22-14-5-3-4-12(8-14)13-6-7-16-15(9-13)18(19)21-11-20-16/h3-9,11H,10H2,1-2H3,(H,22,24)(H2,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair