BDBM299550 6-[3-(2-pyrrolidin- 1-ylethoxy) phenyl]pyrido [3,2-d]pyrimidin- 4-amine::US9592235, Example 320::US9855269, Compound 169

SMILES: Nc1ncnc2ccc(nc12)-c1cccc(OCCN2CCCC2)c1

InChI Key: InChIKey=JZMWZQOVPAAPEP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299550   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299550 (6-[3-(2-pyrrolidin- 1-ylethoxy) phenyl]pyrido [3,2...) Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(OCCN2CCCC2)c1 Show InChI InChI=1S/C19H21N5O/c20-19-18-17(21-13-22-19)7-6-16(23-18)14-4-3-5-15(12-14)25-11-10-24-8-1-2-9-24/h3-7,12-13H,1-2,8-11H2,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299550 (6-[3-(2-pyrrolidin- 1-ylethoxy) phenyl]pyrido [3,2...) Show SMILES Nc1ncnc2ccc(nc12)-c1cccc(OCCN2CCCC2)c1 Show InChI InChI=1S/C19H21N5O/c20-19-18-17(21-13-22-19)7-6-16(23-18)14-4-3-5-15(12-14)25-11-10-24-8-1-2-9-24/h3-7,12-13H,1-2,8-11H2,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	226	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair