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SMILES: C[C@]1(CC(O)=O)C[C@@H](C(N([C@H](CN(c2ccccc2F)S(=O)(=O)C2CC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key: InChIKey=OQEGKSPKFPABLK-NQRHSHFRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299596   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM299596
PNG
(2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl...)
Show SMILES C[C@]1(CC(O)=O)C[C@@H](C(N([C@H](CN(c2ccccc2F)S(=O)(=O)C2CC2)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Show InChI InChI=1S/C34H35Cl2FN2O5S/c1-34(19-31(40)41)18-27(23-5-4-6-25(36)17-23)32(22-11-13-24(35)14-12-22)39(33(34)42)30(21-9-10-21)20-38(45(43,44)26-15-16-26)29-8-3-2-7-28(29)37/h2-8,11-14,17,21,26-27,30,32H,9-10,15-16,18-20H2,1H3,(H,40,41)/t27-,30-,32?,34-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Amgen, Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...

US Patent US9593129 (2017)


BindingDB Entry DOI: 10.7270/Q20P1232
More data for this
Ligand-Target Pair