BDBM299633 (2S,4S)-5-(3′-Chlorobiphenyl-4-yl)-2-ethoxymethyl-4-[(3-hydroxyisoxazole-5-carbonyl)amino]pentanoic Acid::US9593110, Example 8

SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(=O)OCC

InChI Key: InChIKey=UQKXXHFWGRPQHA-RBBKRZOGSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM299633 ((2S,4S)-5-(3′-Chlorobiphenyl-4-yl)-2-ethoxym...) Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(=O)OCC |r| Show InChI InChI=1S/C26H29ClN2O6/c1-3-33-16-20(26(32)34-4-2)14-22(28-25(31)23-15-24(30)29-35-23)12-17-8-10-18(11-9-17)19-6-5-7-21(27)13-19/h5-11,13,15,20,22H,3-4,12,14,16H2,1-2H3,(H,28,31)(H,29,30)/t20-,22+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Theravence Biopharma R&D IP, LLC US Patent					Assay Description Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...				US Patent US9593110 (2017) BindingDB Entry DOI: 10.7270/Q2MC9224
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