BDBM299849 4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)pyridin-3- yl]oxy}methyl) piperidin-1- yl]-6-[(1- cyanocyclopropyl) methoxy]-N- (2,2,2- trifluoroethyl)- 1,3,5-triazine-2- carboxamide::US9593097, Example 219

SMILES: Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(F)(F)F)c1

InChI Key: InChIKey=PVGVNLHBLJRJFY-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM299849 (4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...) Show SMILES Cn1cnc(c1)-c1cnc(N)c(OCC2CCN(CC2)c2nc(OCC3(CC3)C#N)nc(n2)C(=O)NCC(F)(F)F)c1 Show InChI InChI=1S/C26H29F3N10O3/c1-38-10-18(34-15-38)17-8-19(20(31)32-9-17)41-11-16-2-6-39(7-3-16)23-35-21(22(40)33-13-26(27,28)29)36-24(37-23)42-14-25(12-30)4-5-25/h8-10,15-16H,2-7,11,13-14H2,1H3,(H2,31,32)(H,33,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...				US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD
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