BDBM299911 4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)pyridin-3- yl]oxy}methyl) piperidin-1-yl]-N- [(2R)-3-hydroxy-3- methylbutan-2-yl]- 6-[(2R)- tetrahydrofuran-2- ylmethoxy]-1,3,5- triazine-2- carboxamide::US9593097, Example 281
SMILES: C[C@@H](NC(=O)c1nc(OC[C@H]2CCCO2)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1)C(C)(C)O
InChI Key: InChIKey=KVOCVVYYZRCYOY-WIYYLYMNSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM299911 (4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair |