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SMILES: N[C@@H](Cc1ccccc1)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O

InChI Key: InChIKey=SYPMBMOPSHYIOG-IEZKXTBUSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300256   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300256
PNG
(US9593110, 57)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C(O)=O
Show InChI InChI=1S/C29H28ClFN6O4/c30-20-10-11-23(31)22(14-20)19-8-6-18(7-9-19)12-21(34-28(39)26-16-33-37-36-26)15-25(29(40)41)35-27(38)24(32)13-17-4-2-1-3-5-17/h1-11,14,16,21,24-25H,12-13,15,32H2,(H,34,39)(H,35,38)(H,40,41)(H,33,36,37)/t21-,24+,25-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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KEGG
PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair