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BDBM300275 US9593110, 2-12

SMILES: COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(Cl)cn1)C(O)=O

InChI Key: InChIKey=AVQZILBNPZBPHX-FXAWDEMLSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300275   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300275
PNG
(US9593110, 2-12)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(Cl)cn1)C(O)=O
Show InChI InChI=1S/C25H23Cl2FN2O4/c1-34-14-17(25(32)33)11-20(30-24(31)23-9-7-19(27)13-29-23)10-15-2-4-16(5-3-15)21-12-18(26)6-8-22(21)28/h2-9,12-13,17,20H,10-11,14H2,1H3,(H,30,31)(H,32,33)/t17-,20+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair