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BDBM300279 US9593110, 2-14

SMILES: COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(cn1)C(F)(F)F)C(O)=O

InChI Key: InChIKey=YVQDONHLOZXBSO-FXAWDEMLSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300279   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300279
PNG
(US9593110, 2-14)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(cn1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C26H23ClF4N2O4/c1-37-14-17(25(35)36)11-20(33-24(34)23-9-6-18(13-32-23)26(29,30)31)10-15-2-4-16(5-3-15)21-12-19(27)7-8-22(21)28/h2-9,12-13,17,20H,10-11,14H2,1H3,(H,33,34)(H,35,36)/t17-,20+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair