BindingDB logo
myBDB logout

BDBM300281 US9593110, 2-15

SMILES: COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O

InChI Key: InChIKey=VIPAZHQHKGUKTB-PKOBYXMFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300281   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300281
PNG
(US9593110, 2-15)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O5/c1-14-12-27-23(33-14)22(29)28-19(10-17(13-32-2)24(30)31)9-15-3-5-16(6-4-15)20-11-18(25)7-8-21(20)26/h3-8,11-12,17,19H,9-10,13H2,1-2H3,(H,28,29)(H,30,31)/t17-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair