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BDBM300292 US9593110, 7-1

SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O

InChI Key: InChIKey=AABIHRPKNRHYNW-FUHWJXTLSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300292   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300292
PNG
(US9593110, 7-1)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C23H24ClFN4O4/c1-2-33-13-16(23(31)32)10-18(27-22(30)21-12-26-29-28-21)9-14-3-5-15(6-4-14)19-11-17(24)7-8-20(19)25/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,30)(H,31,32)(H,26,28,29)/t16-,18+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair