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BDBM300294 US9593110, 7-2

SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1[nH]nc(C2CC2)c1F)C(O)=O

InChI Key: InChIKey=RQCNZKAATWTZTF-AZUAARDMSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300294   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300294
PNG
(US9593110, 7-2)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1[nH]nc(C2CC2)c1F)C(O)=O
Show InChI InChI=1S/C27H28ClF2N3O4/c1-2-37-14-18(27(35)36)12-20(31-26(34)25-23(30)24(32-33-25)17-7-8-17)11-15-3-5-16(6-4-15)21-13-19(28)9-10-22(21)29/h3-6,9-10,13,17-18,20H,2,7-8,11-12,14H2,1H3,(H,31,34)(H,32,33)(H,35,36)/t18-,20+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair