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BDBM300295 US9593110, 7-3

SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O

InChI Key: InChIKey=UQMPEAUJHZKAQW-AZUAARDMSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300295   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300295
PNG
(US9593110, 7-3)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O
Show InChI InChI=1S/C26H27ClFN3O5/c1-3-36-14-18(26(34)35)11-20(29-25(33)24-13-23(15(2)32)30-31-24)10-16-4-6-17(7-5-16)21-12-19(27)8-9-22(21)28/h4-9,12-13,18,20H,3,10-11,14H2,1-2H3,(H,29,33)(H,30,31)(H,34,35)/t18-,20+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair