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SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1noc(=O)[nH]1)C(O)=O

InChI Key: InChIKey=KBLOJOJIUPCBNX-DOTOQJQBSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300304   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300304
PNG
(US9593110, 7-10)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H23ClFN3O6/c1-2-33-12-15(22(30)31)10-17(26-21(29)20-27-23(32)34-28-20)9-13-3-5-14(6-4-13)18-11-16(24)7-8-19(18)25/h3-8,11,15,17H,2,9-10,12H2,1H3,(H,26,29)(H,30,31)(H,27,28,32)/t15-,17+/m0/s1
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KEGG

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PC cid
PC sid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair