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SMILES: CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncccn1)C(O)=O

InChI Key: InChIKey=WZJFLGUUZOSDMS-AZUAARDMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300305   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300305
PNG
(US9593110, 7-11)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncccn1)C(O)=O
Show InChI InChI=1S/C25H25ClFN3O4/c1-2-34-15-18(25(32)33)13-20(30-24(31)23-28-10-3-11-29-23)12-16-4-6-17(7-5-16)21-14-19(26)8-9-22(21)27/h3-11,14,18,20H,2,12-13,15H2,1H3,(H,30,31)(H,32,33)/t18-,20+/m0/s1
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KEGG

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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair