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SMILES: COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O

InChI Key: InChIKey=GBTNYCPKOFKDSQ-VGOFRKELSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300311   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300311
PNG
(US9593110, 30-2)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O
Show InChI InChI=1S/C25H24ClFN4O6/c1-13(32)20-12-21(31-30-20)23(33)28-17(11-22(24(34)35)29-25(36)37-2)9-14-3-5-15(6-4-14)18-10-16(26)7-8-19(18)27/h3-8,10,12,17,22H,9,11H2,1-2H3,(H,28,33)(H,29,36)(H,30,31)(H,34,35)/t17-,22-/m1/s1
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PC cid
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair