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BDBM300318 US9593110, 30-7

SMILES: CCOc1nc(co1)C(=O)N[C@@H](C[C@@H](NC(=O)OC)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F

InChI Key: InChIKey=AUIPEKCLFDOGQQ-YLJYHZDGSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300318   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300318
PNG
(US9593110, 30-7)
Show SMILES CCOc1nc(co1)C(=O)N[C@@H](C[C@@H](NC(=O)OC)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C25H25ClFN3O7/c1-3-36-25-30-21(13-37-25)22(31)28-17(12-20(23(32)33)29-24(34)35-2)10-14-4-6-15(7-5-14)18-11-16(26)8-9-19(18)27/h4-9,11,13,17,20H,3,10,12H2,1-2H3,(H,28,31)(H,29,34)(H,32,33)/t17-,20-/m1/s1
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KEGG

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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair