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BDBM300347 US9593110, 16-23

SMILES: Cc1ccccc1-c1n[nH]c(C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc2ccc(cc2)-c2cc(Cl)ccc2F)c1F

InChI Key: InChIKey=GCHSLIKXPJABKK-AUSIDOKSSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 300347   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM300347
PNG
(US9593110, 16-23)
Show SMILES Cc1ccccc1-c1n[nH]c(C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc2ccc(cc2)-c2cc(Cl)ccc2F)c1F
Show InChI InChI=1S/C28H25ClF2N4O3/c1-15-4-2-3-5-20(15)25-24(31)26(35-34-25)27(36)33-19(14-23(32)28(37)38)12-16-6-8-17(9-7-16)21-13-18(29)10-11-22(21)30/h2-11,13,19,23H,12,14,32H2,1H3,(H,33,36)(H,34,35)(H,37,38)/t19-,23-/m1/s1
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US Patent
<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...

US Patent US9593110 (2017)


BindingDB Entry DOI: 10.7270/Q2MC9224
More data for this
Ligand-Target Pair