BDBM3005 3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-d]pyrimidine::3-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine::pyrazolopyrimidine deriv. 6

SMILES: Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12

InChI Key: InChIKey=ZDNMTYMNWKRHQA-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM3005 (3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...) Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12 Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Protein Kinase C, alpha (Bos taurus (bovine))	BDBM3005 (3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...) Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12 Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	7.5	n/a
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM3005 (3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...) Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12 Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase transforming protein Abl (Abelson murine leukemia virus)	BDBM3005 (3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...) Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12 Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	7.5	20
Novartis Pharmaceuticals					Assay Description IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...				J Med Chem 40: 3601-16 (1997) Article DOI: 10.1021/jm970124v BindingDB Entry DOI: 10.7270/Q2H70D0N
					More data for this Ligand-Target Pair