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SMILES: Cn1cc(cn1)-n1nc(cc1NC(=O)Nc1cncc(c1)C(=O)c1cn(C)c2ncncc12)C(C)(C)C

InChI Key: InChIKey=GNEBMKVTKNJING-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30054   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM30054
PNG
(US8846698, 527)
Show SMILES Cn1cc(cn1)-n1nc(cc1NC(=O)Nc1cncc(c1)C(=O)c1cn(C)c2ncncc12)C(C)(C)C
Show InChI InChI=1S/C25H26N10O2/c1-25(2,3)20-7-21(35(32-20)17-10-29-34(5)12-17)31-24(37)30-16-6-15(8-26-9-16)22(36)19-13-33(4)23-18(19)11-27-14-28-23/h6-14H,1-5H3,(H2,30,31,37)
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Similars
US Patent
n/an/a 4.64n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...

US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair